血流感染和血细胞新生体的风险:基于人口的队列研究
Adam G Stewart1,2,3, Felicity Edwards4, Kevin B Laupland4,5
1Transplant and Immunocompromised Host Infectious Diseases, Department of Medicine, Infectious Diseases Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
概括
血流感染 (BSI) 显著增加了随后诊断的血细胞瘤的风险. 肺炎链球菌BSI显示了最高的关联,突出显示BSI是隐性血细胞瘤的标志物.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 侵入性感染可能表明潜在的血细胞新生体.
- 血流感染 (BSI) 可能是一个早期的迹象,促使对隐性血细胞瘤进行调查.
研究的目的:
- 为了量化血流感染 (BSI) 后随后的血细胞瘤诊断的风险.
主要方法:
- 从2000年到2019年,基于人口的监测.
- 鉴定了患有血细胞新生病的患者,在BSI的一年内诊断出.
- 包括90名患有BSI的患者在先前诊断出瘤和95,753名对照.
主要成果:
- 一个BSI与血细胞瘤诊断的风险增加了13倍 (IRR 12.9).
- 在女性中,风险更高 (IRR 14.0).
- 肺炎链球菌BSI显示的风险最高 (IRR 46.9).
结论:
- BSI,特别是S. pneumoniae,在一组患者中作为隐性血细胞瘤的标志物.
- 需要进一步的研究来制定针对发生BSI的患者的调查策略.
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