纤维肌痛妇女便微生物群:功能组成和症状相关性
Sharon Erdrich1, Ingrid C Gelissen1, Ryan Toma2
1School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
纤维肌痛患者没有显示出整体肠道微生物差异. 然而,特定的细菌与认知问题和腹膜疼痛有关,这表明纤维肌痛中肠-大脑轴连接.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
背景情况:
- 纤维肌痛是一种复杂的慢性疼痛障碍.
- 肠道微生物群在纤维肌痛中的作用尚不清楚.
- 肠-大脑相互作用障碍 (DGBI) 在纤维肌痛患者中很常见.
研究的目的:
- 为了比较患有纤维肌痛的女性与对照者的肠道微生物群组成.
- 为了研究便微生物群和纤维肌痛症状之间的关系.
- 探索与疼痛,DGBI,睡眠,认知和生活质量的关联.
主要方法:
- 从纤维肌痛患者 (n=104) 和对照组 (n=52) 的女性便样本进行了metatranscriptomic分析.
- 经过验证的调查评估了临床特征,包括疼痛,DGBI,睡眠,认知和生活质量.
- 统计分析包括相关性,t测试和通用线性模型,控制错误发现率.
主要成果:
- 纤维肌痛患者和对照人群之间的便微生物表达没有显著的整体差异.
- 细菌类Bacteroidetes的特定物种与认知障碍有关.
- Fusobacteriota族群与罗马IV (B) DGBI显著相关,特别是表胃疼痛综合征.
- 便中的口腔微生物群与胃肠上部DGBI有很强的相关性.
结论:
- 在纤维肌痛患者和对照患者之间,的总体微生物组成没有差异.
- 细菌类 (Bacteroidetes) 和菌类 (Fusobacteriota) 分别与认知障碍和上胃疼痛综合征有关.
- 这些发现表明,纤维肌痛相关症状的潜在微生物点.
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