酸促进食物过敏通过树突细胞介导的免疫干扰
Zhencong Yang1, Xue Feng2, Philippe Madjirebaye1
1School of Public Health, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060 Guangdong Province, PR China.
Journal of agricultural and food chemistry
|September 19, 2025
概括
酸盐 (SN) 是一种常见的食品防腐剂,通过破坏免疫平衡,使食物过敏症状恶化. 暴露于SN会增强过敏反应和免疫细胞的激活,可能会增加食物过敏的严重程度.
科学领域:
- 免疫学 免疫学 免疫学
- 食品科学 食品科学 食品科学
- 毒理学 毒理学 毒理学
背景情况:
- 酸盐 (SN) 被广泛用作食品防腐剂.
- 它对食物过敏 (FA) 病原和免疫调节的影响尚不清楚.
研究的目的:
- 为了研究亚慢性SN暴露对树突细胞 (DC) 介导的敏感化和T细胞极化在卵胺 (OVA) 诱导的食物过敏的小鼠模型的影响.
主要方法:
- 利用OVA诱导的食物过敏的小鼠模型.
- 评估了临床过敏症状,体重增加,血清标记物 (组胺,MCP-1,IgE),T细胞极化 (T-bet/GATA3,Treg),DC激活,以及体外免疫细胞反应.
主要成果:
- 暴露于SN会加剧过敏反应,包括增加的临床症状,减少体重增加,以及升高的组胺,MCP-1和IgE.
- 通过破坏T-bet/GATA3平衡,抑制调节性T细胞 (Tregs) 和增强DC激活,SN促进了Th2极化.
- 在体外,SN增强了DC抗原吸收,MHC II表达,并激活了MAPK和STAT6通路,导致Th2细胞因子和IgE增加.
结论:
- 通过调节DC功能,Th2极化和调节机制,SN破坏免疫恒温,加剧食物过敏.
- 这些发现凸显了SN通过多种免疫调节途径恶化食物过敏的潜力.
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