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改善1型糖尿病的时间范围:预测自动化胰岛素输送的临床和成本影响
Sufyan Hussain1,2,3, Asli Zeynep Ozdemir Saltik4, Jessica J Yu4
1Department of Diabetes, School of Cardiovascular, Metabolic Medicine and Sciences, King's College London, London, United Kingdom.
Diabetes technology & therapeutics
|September 19, 2025
概括
改善1型糖尿病 (PwT1D) 患者的治疗时间 (TIR) 显著减少并发症和医疗费用. 即使是10%的TIR增加也会带来实质性的临床和经济效益,特别是对于那些基线TIR较低的人来说.
科学领域:
- 内分泌学和新陈代谢学
- 卫生经济学 卫生经济学
- 糖尿病管理 糖尿病管理
背景情况:
- 范围内的时间 (TIR) 是管理1型糖尿病 (T1D) 的关键指标,与减少并发症率有关.
- 目前的健康经济评估很少将TIR作为主要结果指标.
- 本研究研究了改善TIR在1型糖尿病患者 (PwT1D) 的临床和经济影响.
研究的目的:
- 量化PwT1D的TIR增加10个百分点的临床和经济效益.
- 预测对并发症发生率,预期寿命和医疗保健成本的长期影响.
- 分析不同基线TIR级别的这些影响.
主要方法:
- 利用两种统计方法绘制基线TIR水平和10%的TIR增加以估计糖化血红蛋白 (HbA1c).
- 采用IQVIA CORE糖尿病模型来预测累积并发症发生率,预期寿命,质量调整后预期寿命 (QALE) 和超过20年的成本.
- 来自国家卫生和护理卓越研究所 (NICE) 经济评估的队列数据,并发症成本和公用事业.
主要成果:
- 10个百分点的TIR增加显著降低了眼科,脏,神经病和心血管并发症的累积发病率 (从8.1%到53.0%不等).
- 预计的收益包括预期寿命 (0.031-0.051年) 和QALE (0.056-0.143年) 的增加,在较低的基线TIR中收益更大.
- 总的预计成本降低在7.5%至9.9%之间,主要是由于并发症治疗费用减少.
结论:
- 预计TIR增加10个百分点将减少英国糖尿病并发症和PwT1D相关治疗费用.
- 改善TIR的临床和经济效益在所有基线水平上都被观察到,但在基线TIR较低的个体中更为明显.
- 这凸显了针对TIR改善糖尿病管理策略的重要性,以提高患者的治疗成果和节省成本.
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