循环水平与动脉硬度之间的关联:全国性的横截面研究
Kunsheng Zhao1, Lei Qiao2, Wenqi Hu1
1Department of Health Management, Shandong Engineering Research Center of Health Management, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Health Management, Jinan, People's Republic of China.
International journal of surgery (London, England)
|September 19, 2025
概括
循环 (Cse) 水平显示出与动脉硬的复杂关系,由高脉冲波速度 (ePWV) 和血动脉原性指数 (AIP) 表示. 较低的Cse水平与减少的ePWV相关,而较高的Cse水平则增加了ePWV.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 生物标志物 生物标志物
背景情况:
- 动脉样性心血管疾病 (ASCVD) 是全球主要的死亡原因.
- 动脉硬是ASCVD的一个关键病理特征.
- (Se) 在动脉硬性中的作用尚未完全理解,特别是循环Se (Cse) 水平与动脉硬性之间的联系.
研究的目的:
- 调查循环 (Cse) 水平与动脉硬的标志物之间的关联.
- 探索Cse水平,估计的脉冲波速度 (ePWV) 和血的动脉动原指数 (AIP) 之间的关系.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) (2011-2018) 的11,937名参与者的分析.
- 使用单变量和多变量线性回归,剂量反应和调解分析来评估关系.
- 研究了Cse级别,ePWV和AIP之间的关联.
主要成果:
- 在Cse水平和高 ePWV (P < 0.001) 之间观察到U形关系.
- 低于2.99μmol/L的Cse水平与较低的ePWV相关 (OR=0.71),而2.99μmol/L或以上的Cse水平与较高的ePWV相关 (OR=2.66).
- 在Cse和高AIP (OR=1.48) 之间发现了积极的关联,性别调解了这种关系 (26.49%的调解).
结论:
- 循环水平与动脉硬度标志物,ePWV和AIP有显著的相关性.
- 这种复杂的非线性关系表明对动脉硬的影响存在值效应.
- 需要进一步的研究来阐明Cse与动脉硬相关的潜在机制.
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