大脑连接的变化通过行为抑制系统影响焦虑
Runyang He1, Yan Zhu1, Jiayu Ye1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu 611731, P. R. China.
International journal of neural systems
|September 19, 2025
概括
这项研究发现,行为抑制系统 (BIS) 的更高灵敏度与大脑网络相互作用的时间变化更大相关,特别是涉及注意力和感官网络. 这种大脑活动模式与焦虑有关.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 认知科学 认知科学
背景情况:
- 行为抑制系统 (BIS) 对于处理惩罚线索和避免行为至关重要,并且与焦虑有关.
- 神经动力学,特别是大脑网络相互作用的时间变化,BIS功能的基础并未得到充分理解.
研究的目的:
- 研究BIS灵敏度与大脑网络功能连接的时间变异性之间的关联.
- 探索BIS功能的神经基础及其与焦虑的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 用于181名健康成年人.
- 分析了大脑网络内部和大脑网络之间的功能连接的时间变化.
- 与网络变化度量相关联的BIS敏感度得分.
主要成果:
- 在BIS分数和感官体运动手网络 (SSHN) -腹部注意网络 (VAN) 和感觉体运动口网络 (SSMN) -VAN之间的连接时间变异之间发现了显著的正相关性.
- 与BIS敏感度较低的人相比,具有高BIS敏感度的个体在VAN和SSMN/SSHN之间表现出更大的时间变化.
- 基于网络可变性的预测BIS得分与实际BIS得分有很强的相关性,BIS得分调解了网络可变性和焦虑之间的关系.
结论:
- 特定大脑网络相互作用的时间变化与BIS敏感性有关.
- 这些发现提供了关于BIS和焦虑背后的神经机制的见解.
- 这项研究有助于了解焦虑障碍的病原性.
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