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在口腔癌中,除了完全反应之外:患者和瘤相关因素

Francesco Mattioli^1,2, Matteo Miglio^1,2, Edoardo Serafini³

¹Department of Otorhinolaryngology-Head and Neck Surgery University Hospital of Modena Modena Italy.

Laryngoscope investigative otolaryngology

|September 19, 2025

概括

这项研究确定了在接受非手术治疗的口腔状细胞癌患者治疗反应的预测因素. 识别不响应的瘤表型可以改进治疗策略和口腔癌的后续计划.

科学领域:

在瘤学瘤学.
头部和部癌症研究研究
癌症治疗响应反应癌症治疗响应

背景情况:

口腔癌 (OPC) 是一个重要的健康问题,需要有效的治疗策略.
预测对非手术治疗治疗的反应对于优化患者的治疗结果至关重要.
了解影响治疗反应的瘤和患者特征对于OPC个性化医学至关重要.

研究的目的:

为了确定与瘤和患者相关的因素,预测口腔膜状细胞癌 (OPSCC) 的非手术治愈治疗反应.
在一组OPSCC患者中定义瘤结果,包括整体存活率和无进展存活率.
根据影响治疗反应的因素对患者进行分层,以便更好地进行治疗和后续计划.

主要方法:

一个单一的回顾性队列研究包括223名非转移性OPSCC患者,接受了治疗意图的非手术治疗.
数据来自于2010年1月至2021年12月期间在意大利莫德纳大学医院接受治疗的患者.
使用RECIST 1.1标准对治疗后3个月的成像进行治疗反应的评估.

主要成果:

桃体亚部位和I阶段独立地与完整的治疗反应有关.
吸烟和p16状态与不完全反应的更高概率有关.
特定的子部位 (软 palates),T阶段 (cT4),N阶段 (N2在p16+),和整体阶段 (IVb在p16-) 显示了不同的响应关联;cT1预测了更高的完整响应率.

结论:

这项回顾性研究表明,患者分层基于影响OPSCC治疗反应的因素.
识别不响应的瘤表型可以改善治疗和后续计划.
进一步的研究可以根据这些预测因素来完善口腔状细胞癌的治疗策略.

关键词:

人类乳头瘤病毒人类乳头瘤病毒口腔喉皮状细胞癌的发生.这是一个渐进的过程.复发性复发性复发性对治疗的反应.

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