预后营养指数的预后值在为胃癌进行手术的患者中
Fırat Mülküt1, Cem Batuhan Ofluoğlu1, Mustafa Kağan Başdoğan1
1General Surgery Department, Martyr Dr. İlhan Varank Sancaktepe Training and Research Hospital, Dudullu¸ Türkiye.
Frontiers in surgery
|September 19, 2025
概括
预后营养指数 (PNI) 有效地预测胃癌患者的长期存活率和术后并发症. 较低的PNI值与更高的风险有关,特别是在密封环细胞癌中,强调需要进行营养监测.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 胃癌是全球癌症死亡的主要原因之一.
- 营养不良显著影响胃癌患者的治疗结果和治疗反应.
- 预后营养指数 (PNI) 是营养状况的潜在标志物.
研究的目的:
- 研究PNI对胃癌患者术后并发症和长期存活率的影响.
- 为了比较不同胃癌组织学亚型的PNI值.
- 确定PNI作为胃癌的独立预后因素.
主要方法:
- 对220名经过治愈切除术的胃癌患者 (2014-2020年) 的回顾性分析.
- 使用血清白蛋白和淋巴细胞计数计算PNI.
- ROC分析以确定最佳的PNI截止值 (46.2).
- 评估PNI与临床病理特征,并发症和5年整体存活率 (OS) 的相关性.
主要成果:
- 患PNI<46.2的患者表现出明显更高的并发症率 (p=0.006) 和更短的5年生存期 (p=0.001).
- 标签环细胞癌 (SRCC) 亚型显示明显较低的PNI值 (p=0.001).
- 低PNI与周围神经和淋巴血管入侵有关.
- 瘤阶段和PNI是5年生存期的独立预后因素.
结论:
- 在胃癌中,PNI是预测存活率和术后并发症的有价值标志物.
- 在SRCC中较低的PNI需要对这一子组的营养状况进行更密切的监测.
- 术前PNI评估可以帮助胃癌患者个性化治疗规划.
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