在CPAP治疗阻塞性睡眠呼吸暂停之前和之后的黑色素和皮质醇度
Khue Bui-Diem1, Nguyen Van Tho2, Thu Nguyen-Binh1
1Department of Physiology - Pathophysiology - Immunology - Pharmacology, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Nature and science of sleep
|September 19, 2025
概括
针对阻塞性睡眠呼吸暂停 (OSA) 的持续正气道压力 (CPAP) 疗法显示趋势是使唾液中的黑激素和皮质醇水平正常化. 需要进一步的研究来证实这些发现作为治疗疗效的生物标志物.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 生物标志物 生物标志物
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与下丘脑-垂体-上腺 (HPA) 轴和昼夜节律的失调有关.
- 唾液中的黑激素和皮质醇是这些激素失衡的潜在指标.
研究的目的:
- 在患有OSA的患者中,在持续正气道压力 (CPAP) 治疗之前和之后调查唾液中黑激素和皮质醇度的变化.
- 评估这些激素作为CPAP疗效生物标志物的潜力.
主要方法:
- 一项前性研究涉及59名患有OSA的成年人,其中27人完成了为期8周的CPAP随访.
- 用ELISA测量早晨和下午样本中的唾液黑激素和皮质醇.
- 分析使用威尔科克森签名等级测试和斯皮尔曼相关性.
主要成果:
- 基线平均黑激素为80.80 pg/mL (下午较高),皮质醇为7.58 ng/mL (上午较高).
- 在CPAP后,黑激素降至63.78 pg/mL,皮质醇增加至8.06 ng/mL.
- 荷尔蒙变化没有统计学意义 (p>0.05);黑激素与茶饮有负相关性.
结论:
- 趋势表明CPAP可能会降低睡眠压力,这是下午较低的黑激素和较高的皮质醇所表明的.
- 显著的中断率限制了解释;需要进行更大的研究.
- 需要进一步进行综合激素评估的研究,以了解OSA昼夜控制中的唾液生物标志物.
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