系统性免疫炎症指数和慢性病死亡率
Yanshuang Ma1,2, Yang Yu3, Zhongdan Jia1
1Department of Hyperbaric Oxygen, First Hospital of Jilin University, Changchun, Jilin, China.
Frontiers in endocrinology
|September 19, 2025
概括
系统性免疫炎症指数 (SII) 显示了慢性病 (CKD) 患者的死亡率与U形关系. 超过一定值的较高SII水平会增加所有死因和心血管疾病的死亡风险.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物统计学 生物统计学
背景情况:
- 慢性病 (CKD) 是一种普遍的疾病,与死亡率的增加有关.
- 系统性免疫炎症指数 (SII) 与CKD患者的死亡率之间的关系尚不清楚.
研究的目的:
- 研究慢性病 (CKD) 患者的系统性免疫炎症指数 (SII) 和死亡率之间的关联.
- 确定SII是否可以作为CKD患者死亡率的预测标记.
主要方法:
- 在46,620名患有CKD的人群中进行了多变量Cox回归分析.
- 分析了生存数据和值效应,以评估SII和死亡率之间的关系.
- 进行了子组分析,以评估不同年龄组的预测能力.
主要成果:
- 在日志转换SII (SII.log) 与全因和心血管疾病 (CVD) 死亡率之间观察到非线性U形相关性.
- 死亡风险最初随着SII.log的上升而下降,但超过6.06和6.25的门后显著增加.
- 较高的SII水平与生存率降低有关,SII可靠地预测了45岁以上CKD患者的全因死亡率.
结论:
- 系统性免疫炎症指数 (SII) 是一种随时可用的标志物,可以预测45岁以上的CKD患者的死亡率.
- 建议进行进一步的纵向研究,以确认SII对CKD全因,心血管和癌症死亡率的预测价值.
- 该研究强调了SII作为预后工具在治疗CKD患者中的潜力.
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