肠道微生物组与宿主基因之间的相互作用在调节Cynoglossus semilaevis中的振动症耐药性方面
Weiwei Zheng1, Yadong Chen1, Tao Yang1
1State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, China.
Frontiers in immunology
|September 19, 2025
概括
病毒感染严重损害了中国人的舌头单肠,改变了肠道微生物和宿主基因表达. 基因与微生物的相关性表明,基因在疾病耐药性方面起着作用,需要进一步研究.
科学领域:
- 水生微生物学 水生微生物学
- 鱼类免疫学 鱼类免疫学
- 基因组学就是基因组学.
背景情况:
- 中国的舌水产养殖面临着严重的损失,原因是病爆发.
- 人们对肠道微生物组和宿主基因相互作用在耐震症抵抗中的作用知之甚少.
研究的目的:
- 调查肠道组织病理学,微生物组和宿主基因表达变化在中国舌头底后Vibrio harveyi感染.
- 确定肠道微生物和宿主基因在耐药和易感个体之间的相关性.
主要方法:
- 肠道组织的组织病理学分析.
- 16S rRNA测序用于微生物社区概况.
- 用于宿主基因表达分析的RNA测序 (RNA-seq).
- 微生物和基因表达数据的综合分析.
主要成果:
- 易受感染的鱼类表现出显著的肠道组织损伤和改变的微生物组成 (增加了Vibrio,减少了其他属).
- 敏感的鱼类表现出更多的差异表达基因 (DEGs),丰富了与免疫相关的途径.
- 在肠道微生物和宿主DEG之间确定了207个强烈的相关性.
结论:
- 哈维菌感染会对肠道健康产生负面影响,并改变宿主微生物组的动态.
- 基因与微生物的相关性表明,在调节振动症耐药性方面存在潜在的相互作用,尽管因果关系需要进一步调查.
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