慢性阻塞性肺病中全身炎症反应指数和心房动之间的关联:一个多中心的横截面研究
Hao Xu1, Tianye Li2, Mengya Yang1
1Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Clinical Research Center, Department of Pulmonary and Critical Care Medicine, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
系统性炎症反应指数 (SIRI) 与慢性阻塞性肺病 (COPD) 患者心房动 (AF) 风险较高有关. 升高的SIRI可能有助于预测AF风险,特别是在吸烟者中.
科学领域:
- 医学研究 医学研究
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
背景情况:
- 系统性炎症是慢性阻塞性肺病 (COPD) 和心房动 (AF) 发病的关键.
- 系统性炎症反应指数 (SIRI) 是一种新兴的系统性炎症生物标志物.
- 在COPD患者中,SIRI和AF风险之间的关联尚未得到充分理解.
研究的目的:
- 调查SIRI水平与COPD患者的AF风险之间的关联.
主要方法:
- 一项针对1133名住院COPD患者的多中心横截面研究.
- 根据SIRI水平,患者被分为四分之一.
- 使用多变量逻辑回归,受限立方线 (RCS) 和接收器操作特征 (ROC) 分析.
主要成果:
- 在SIRI上升1单位与4.6%更高的AF风险相关 (OR=1.046).
- 最高的SIRI四分位数显示AF风险增加了116.2%,而最低的四分位数 (OR=2.162) 则增加了116.2%.
- 观察到线性剂量-反应关系;SIRI在与常规因素 (AUC=0.818) 结合时改善了AF预测的准确性.
结论:
- 升高的SIRI独立地与COPD患者的AF风险增加有关,特别是在吸烟者中.
- SIRI可以作为评估COPD中AF风险的实用生物标志物.
- 这突显了系统性炎症在COPD-AF并发症中的作用.
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