一种含有类酶和抑制剂的PMMA骨水泥的配方和特征
Yin-Yu Qi1,2, Lu-Yang Han1,2, Long-Xu Han1
1Bengbu Medical University, The Second People's Hospital of Hefei (Affiliated Hospital) Anhui 230011 China chujianj@mail.ustc.edu.cn xuyang@hfut.edu.cn.
RSC advances
|September 19, 2025
概括
一种新型的类酶A抑制剂 (SrtA I) 装载骨质水泥 (SLBC) 提供了长时间的抗菌活性,可以对抗金黄色葡萄球菌和MRSA. 这种生物相容的水泥显示出在全关节置换中治疗假肢关节感染的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 传染性疾病 传染性疾病
- 整形外科手术 整形外科手术
背景情况:
- 假肢关节感染是凝固全关节置换 (TJR) 的一个重要并发症.
- 目前充满抗生素的骨有持续抗菌功效的局限.
- 排列酶A抑制剂为对抗细菌感染提供了一种新的方法.
研究的目的:
- 开发和评估一种新型的类酶A抑制剂 (SrtA I) 载荷骨质水泥 (SLBC) 治疗假肢关节感染.
- 为了比较SLBC的抗菌功效和材料特性与常规的 gentamicin 装载骨质水泥 (GS水泥).
主要方法:
- 作为SrtA I.1,SLBC的配方是使用1--3,4-二二) -3-二甲基胺) -1-基化物 (AEEK1) 作为SrtA.
- 评估了对黄金葡萄球菌 (S. aureus) 和耐美西林黄金葡萄球菌 (MRSA) 的抗菌持续时间.
- 准静态压力强度,最大聚合温度和设置时间根据ISO 5833标准进行了评估.
- 通过使用猪脊椎的体外和体外研究证实了生物相容性和可注射性.
主要成果:
- 与GS水泥相比,SLBC表现出相对S. aureus和MRSA的有效抗菌持续时间显著延长.
- SLBC的机械性能 (压力强度,聚合温度,定时间) 符合ISO 5833标准,与GS水泥相比.
- 在体外和体外的研究证实了SLBC的生物相容性和易于注射到猪脊椎.
结论:
- SLBC对关节假肢感染相关的关键病原体表现出优越和长期的抗菌活性.
- SLBC具有有利的机械性能和生物相容性,与现有的骨水泥相美.
- SLBC显示出作为一种有效的治疗选择,在凝固TJR中治疗假肢关节感染的巨大潜力.
更多相关视频
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
12.4K
11:20Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
Published on: March 29, 2018
8.0K
相关概念视频
01:18The Bone Matrix
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
01:17Mortar Properties
Mortar properties encompass a range of characteristics crucial for construction and masonry work, including workability, water retention, bond strength, durability, compressive strength, volume change, and appearance. Workability refers to mortar's ability to be easily applied and manipulated without sagging or falling off surfaces, which is important for efficient masonry unit placement and alignment. Water retention is essential to prevent the mortar from losing moisture too quickly to the...
01:18Porosity in Cement Paste
The porosity of concrete is a measure of the void spaces within its structure. These spaces impact its strength and durability significantly. When water and cement interact, a chemical reaction called hydration creates a semi-solid paste. This paste includes combined water, making up approximately 23% of the cement's dry mass, and gel water, which fills minuscule voids known as gel pores, accounting for about 28% of the cement gel volume.
The balance of water to cement in the mix is critical—it...
The balance of water to cement in the mix is critical—it...
01:31Plasticizers
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
01:30Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
01:22Waterproofing and Anti-Bacterial Admixtures in Concrete
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...