可调节的胃内气球用于与代谢功能障碍相关的脂肪性肝病-增强体重减轻和组织学改善
Rakesh Kalapala1, Nitin Jagtap1, Hardik Rughwani1
1Department of Medical Gastroenterology and Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
Journal of clinical and experimental hepatology
|September 19, 2025
概括
可调节的胃内气球 (aIGB) 在患有代谢功能障碍相关的脂肪性肝病/脂肪性肝炎 (MASLD/MASH) 的患者中有效促进显著的体重减轻. 这导致改善肝脏健康和疾病解决,具有有利的安全性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 减肥医学 减肥医学
背景情况:
- 在肥胖个体中,与代谢功能障碍相关的胆固醇性肝病/胆固醇性肝炎 (MASLD/MASH) 具有严重的肝硬化风险.
- 实质性的体重减轻对于MASLD/MASH解决和预防疾病进展至关重要.
研究的目的:
- 为了评估可调节的胃内气球 (aIGB) 放置在诱导减肥方面的有效性.
- 评估aIGB对MASLD/MASH.ASH患者代谢和组织学参数的影响.
- 为了确定aIGB程序的安全性和耐受性.
主要方法:
- 一项前性研究涉及36名患有MASLD/MASH和肥胖症的患者.
- aIGB安置与基线和六个月内镜超声波导向肝活检.
- 主要结果:非酒精性脂肪肝活动指数 (NAS) 的变化;次要结果:体重减轻,ALT水平,纤维化回归.
主要成果:
- 在六个月内,平均总体体重减轻 (TBWL) 为12.65%,其中88.9%的人达到≥5%TBWL.
- 在ALT水平和NAS得分 (91.7%的患者) 显著改善.
- 在55.56%的患者中观察到纤维化改善;向上气球调整与更好的NAS和肥胖症得分相关.
结论:
- aIGB是诱导MASLD/MASH患者显著减肥的有效工具.
- 该程序导致代谢和肝脏组织学参数的显著改善.
- aIGB在肥胖个体中对管理MASLD/MASH表现出良好的安全性.
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