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Updated: Jan 17, 2026

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开发基于PROTAC的策略,用于癌症中的大麻素受体1型 (CB1R) 退化

Aseel Kashkush1, Kisanet Tadesse1, Judith Furth-Lavi1

  • 1The Institute for Drug Research of the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.

ACS pharmacology & translational science
|September 19, 2025
PubMed
概括

使用PROTACs对大麻素受体1型 (CB1R) 的向降解提供了一种新的癌症治疗方法. 这种方法可以选择性地减少癌细胞中的CB1R,抑制瘤生长,没有中枢神经系统的副作用.

关键词:
这就是PROTAC.乳腺癌 乳腺癌 乳腺癌大麻素受体1型 (CB1R)药物设计 药物设计有针对性的降解降解目标.

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