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Updated: Jan 17, 2026

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基因编辑策略,以应对干细胞衍生β细胞治疗1型糖尿病的当前挑战

Jongsoo Han1, Donghyun Lim2, Kisuk Yang1,3,4

  • 1Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Republic of Korea.

Journal of tissue engineering
|September 19, 2025
PubMed
概括

使用CRISPR/Cas9技术的基因编辑显示了增强人类多能干细胞衍生的β细胞 (hPSC-β细胞) 治疗1型糖尿病 (T1D) 的前景. 这些修改旨在改善胰岛素分泌,减少免疫排斥,并减轻潜在T1D疗法的安全问题.

关键词:
增强生物安全性 提高生物安全性增强或纠正的功能功能.基因编辑 基因编辑人类多能干细胞衍生的β细胞.减少免疫排斥 减少免疫排斥

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