标准与增强的基于测量治疗抑郁症的有效性 (EMBED):一个集群随机实施-有效性试验的协议
Raymond W Lam1, Erin E Michalak1, Jill K Murphy2
1Psychiatry, University of British Columbia, Vancouver, CAN.
Cureus
|September 19, 2025
概括
使用微信的基于测量的增强护理 (eMBC) 显示了改善抑郁症治疗结果的希望. 这种方法可以克服标准护理的障碍,使中国和全球的患者受益.
科学领域:
- 心理健康研究 心理健康研究
- 数字健康实施方案
- 临床试验设计 临床试验设计
背景情况:
- 基于测量的护理 (MBC) 改善了主要抑郁障碍 (MDD) 的结果,但面临实施障碍.
- 使用移动应用和微信的增强MBC (eMBC) 可以解决这些挑战.
- eMBC 集成了患者结果跟踪和自我管理支持.
研究的目的:
- 通过微信将eMBC的实施和临床有效性与标准MBC进行比较.
- 评估eMBC对患者结果和治疗坚持的影响.
- 通过定性分析,探索影响eMBC实施的上下文因素.
主要方法:
- 一个混合实施-有效性集群随机试验 (RCT) 在12个上海精神卫生中心.
- 两只手臂:标准的MBC (纸笔) 和eMBC (微信小程序与非专业教练支持).
- 六个月的随访1200名患者和240名医生;混合方法分析.
主要成果:
- 主要实施结果:在六个月内记录患者PHQ-9分数.
- 主要临床结局:六个月后临床缓解 (PHQ-9 ≤4).
- 二次结果包括药物坚持,医生与患者结盟以及成本效益分析.
结论:
- 这项试验将提供关于eMBC与微信在抑郁症治疗中的有效性的证据.
- 结果将指导在中国和国际上更广泛地实施eMBC.
- 通过数字工具,eMBC有可能增强精神卫生保健服务的提供.
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