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在接受常规透析和在线血液过的患者中,平均血小板体积的预测值
Diana D Nenova1,2, Yanko G Yankov3,4
1Second Department of Internal Disease, Medical University "Prof. Dr. Paraskev Stoyanov", Varna, BGR.
Cureus
|September 19, 2025
概括
更高的平均血小板体积 (MPV) 表明透析患者心血管风险和死亡率增加. 在线血液过 (OL-HDF) 可以通过改善结果和降低血小板反应性来降低这种风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 心血管医学 心血管医学
背景情况:
- 末期脏疾病 (ESRD) 患者的死亡率更高,主要来自心血管疾病 (CVD).
- 平均血小板体积 (MPV) 和MPV与血小板计数比率 (MPR) 是心血管风险 (CVR) 的潜在标志物,但在透析患者中研究不足.
- 透析疗法如血液透析 (HD) 和在线血液过 (OL-HDF) 可能会影响血小板活性和心血管回路.
研究的目的:
- 调查MPV和MPR作为CVR和ESRD患者在HD和OL-HDF中的死亡率的潜在标志物.
- 评估HD和OL-HDF对血小板活动的影响.
- 在透析患者中确定CVR分层的成本有效标记物.
主要方法:
- 在两年内 (41名ESRD患者的回顾性分析 (2020-2021年).
- 评估血小板参数 (MPV,PLT,MPR),透析的充分性,营养状况,贫血控制和死亡率.
- 对接受OL-HDF和常规HD的患者之间的结局进行比较.
主要成果:
- OL-HDF患者表现出更好的透析充分性,营养状况和血红蛋白水平,与较低的红素蛋白剂量.
- 与OL-HDF患者相比,患HD的患者的MPV显著更高,MPR更低.
- 较高的MPV (>10.5 fL) 与5.59倍的死亡相对风险增加有关.
- 在两组中,MPV和红素蛋白剂量之间发现了正相关性.
结论:
- 升高的MPV与透析患者的临床恶化和死亡风险增加有关.
- 像OL-HDF这样的对流疗法可以通过改善临床结果和减少血小板反应性来降低死亡率.
- MPV和MPR是ESRD患者CVR评估的可访问和成本效益的生物标志物,有助于临床决策.
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