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Updated: Jan 17, 2026

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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在KRAS的局部序列上下文调节DNA修复效率:从分子动力学模拟的见解

James Davies1, Georgina E Menzies1

  • 1Molecular Biosciences Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom.

Frontiers in molecular biosciences
|September 19, 2025
PubMed
概括

[a]二醇氧化物 (BPDE) adducts 首选损害KRAS编码子12,由于DNA结构的改变而逃避修复. 这种受损的核酸切除修复 (NER) 在代码子12有助于癌症的发展.

关键词:
在 BPDEDE 中,修复DNA的修复DNA的修复克拉斯 (Kras) 是一个国家.在Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4Rad4分子动力学分子动力学

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