相关实验视频
Updated: Jan 17, 2026

10:52
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
5.5K
遗传性蛋白C缺乏症的多系统栓塞与圆孔:一个案例报告
Lihua Chen1, Jianhua Guan2, Yunfeng Ni3
1Department of Encephalopathy, The Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Frontiers in cardiovascular medicine
|September 19, 2025
概括
遗传性蛋白C缺乏症 (HPCD) 与圆孔 (PFO) 相结合,可能导致危险的多系统血栓塞. 早期诊断和联合治疗对于患者的康复和预防复发事件至关重要.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 遗传学 遗传学 是一个
背景情况:
- 遗传性蛋白C缺乏症 (HPCD) 是一种罕见的遗传性血栓友爱症.
- 专利卵孔 (PFO) 与右至左的分流 (RLS) 增加了栓塞风险.
- HPCD和PFO对多系统血栓塞的联合作用没有报告.
研究的目的:
- 报告第一个多系统血栓塞的病例,原因是同时存在的HPCD和PFO.
- 为了突出这些疾病的协同性血栓风险.
- 强调全面评估和治疗的重要性.
主要方法:
- 一个29岁的女人有着无法解释的意识改变的病例报告.
- 诊断工作包括成像 (动脉,静脉,肺),对PROC变体进行基因分析,以及对PFO和RLS进行对比的心声学.
- 治疗包括机械血栓切除术,IVC过器,PFO关闭和抗凝剂.
主要成果:
- 这位患者出现了基底动脉封闭,肺栓塞和静脉血栓症.
- 已确认异性致病性PROC变体和PFO具有3级RLS.
- 成功治疗导致了完全的临床康复,并在1年的随访期间没有复发事件.
结论:
- 同时存在的HPCD和PFO对多系统血栓塞栓症具有显著的协同作用风险.
- 在患有不明原因血栓塞的患者中,对这两种情况进行彻底评估至关重要.
- 个性化治疗策略,包括PFO关闭和抗凝药,对于有利的结果至关重要.
相关概念视频
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
329
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
329
Pulmonary Embolism I: Introduction
521
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
521
Pulmonary Embolism III: Nursing Management
364
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
364
Pulmonary Hypertension: Classification and Pathogenesis
580
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
580
Mitral Stenosis I: Introduction
483
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
483
Aneurysm II: Clinical Manifestations and Diagnostic Studies
303
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
303

