肺动脉高血压的死亡率和趋势,1990-2021年:基于人口的研究
Linhong Jiang1, Xinliao Deng1, Yuchen He1
1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in cardiovascular medicine
|September 19, 2025
概括
全球肺动脉高血压 (PAH) 死亡率下降,但由于人口增长和老龄化,死亡人数增加. 针对性的诊断和治疗对于降低PAH死亡率至关重要.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 心血管研究研究心血管研究
背景情况:
- 肺动脉高血压 (PAH) 是一种严重的疾病,死亡率高.
- 缺乏关于PAH死亡率流行病学的综合数据.
- 了解PAH死亡率趋势对于公共卫生干预至关重要.
研究的目的:
- 从1990年到2021年分析肺动脉高血压 (PAH) 的全球,区域和国家死亡率趋势.
- 预测未来15年的PAH死亡率趋势.
- 调查与PAH死亡率相关的健康不平等.
主要方法:
- 利用了2021年全球疾病,伤害和风险因素负担研究 (GBD) 的数据进行PAH估计.
- 员工年龄标准化,以计算PAH的年龄标准化死亡率 (ASMR).
- 分析了时间趋势,预测未来的变化,并分解了死亡率的驱动因素,包括人口和流行病学因素.
主要成果:
- 全球PAH ASMR在1990年至2021年间每年减少了-0.82%,从每10万人口的0.35到0.27.
- 由于人口增长 (93.88%) 和老龄化 (32.26%),PAH总死亡人数从14842人增加了48.37%至22021人.
- 观察到PAH死亡率在跨国健康不平等,不平等指数随着时间的推移而上升.
结论:
- 肺动脉高血压 (PAH) 仍然是一个重要的公共卫生问题,特别是在社会人口统计学指数高的地区.
- 有效的诊断和有针对性的治疗对于减轻PAH相关死亡率至关重要.
- 未来的预测表明,PAH病例数量正在增加,ASMR在很大程度上没有改变.
相关概念视频
Pulmonary Hypertension: Classification and Pathogenesis
580
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
580
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
589
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
589
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
447
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
447
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
567
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
567
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
441
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
441
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
465
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
465


