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相关概念视频

Introduction to Microbial Ecology01:28

Introduction to Microbial Ecology

Microbial ecology examines the complex web of interactions and diversity among microorganisms within various ecosystems. This field seeks to understand how microbial populations adapt to and influence their environments and how these interactions shape broader ecological processes. Microbes are integral to ecosystem function, participating in nutrient cycling, energy flow, and the maintenance of environmental homeostasis.An ecosystem represents a dynamic interaction between living organisms...
iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...

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Updated: Jun 30, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

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建立ELIXIR微生物群体社区

Robert D Finn1, Bachir Balech2, Josephine Burgin1

  • 1European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK.

F1000Research
|September 19, 2025
PubMed
概括
此摘要是机器生成的。

微生物组研究正在扩大,有先进的先进研究.

关键词:
埃利克希尔 社区 社区微生物组是一个微生物组."白皮书"是一本白皮书.

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科学领域:

  • 微生物学 微生物学
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • 微生物组研究已经显著进步,利用诸如元基因组学,元编码学,元转录学和元蛋白质学等技术来探索微生物生物多样性.
  • ELIXIR海洋元基因组学社区一直致力于制定分析微生物组序列数据的标准,并解决方法和参考数据库方面的挑战.

研究的目的:

  • 将ELIXIR海洋元基因组学社区扩大到一个更广泛的ELIXIR微生物群体社区,包括多样化的生物群体.
  • 促进跨各种'omics技术的合作,并改善微生物组研究的生物信息基础设施.

主要方法:

  • 利用先进的'omics技术 (元基因组学,元编码,元转录组学,元蛋白组学) 进行微生物多样性分析.
  • 开发和促进微生物组序列数据分析的标准.
  • 识别和解决微生物组研究的方法和参考数据库的差距.

主要成果:

  • 通过先进的'omics方法了解微生物生物多样性.
  • 微生物组序列分析的确立标准.
  • 确定了微生物组研究计算方面的挑战和解决方案.

结论:

  • 扩大社区以包括多样化的生物群体将加强协作和资源可持续性.
  • 一个统一的微生物群体社区将改善生物信息基础设施,从而更深入地了解微生物群体.
  • 标准化和资源开发对于推动所有生物体的微生物组研究至关重要.