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Updated: May 5, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
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在Salmonella enterica 血清型 Typhi 感染期间巨细胞激活的时间动态:综合转录和代谢组分析

Fanfan Yang1, Yuhui Liu1, Ying Zhang2

  • 1Department of Microorganism Examination, Ningbo Center for Disease Control and Prevention, Ningbo, Zhejiang, China.

Virulence
|September 19, 2025
PubMed
概括

沙门氏菌 Typhi 感染触发了巨细胞中的动态免疫和代谢转变. 这项研究揭示了关键的基因-代谢物相互作用,对于理解宿主-病原体动态和开发疗法至关重要.

关键词:
沙门氏菌输入细胞血清Typhi Typhi在THP-1巨细胞中.感染的感染感染.这是一个代谢组的代谢组.文字转录 字体转录 字体转录

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Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
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