慢性鼻炎中的皮质类固醇反应性嗅觉功能障碍:它意味着什么?
K A Archer1, J C Mace2, T L Smith2
1Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Rhinology
|September 19, 2025
概括
患有慢性鼻炎 (CRS) 和对皮质类固醇敏感的嗅觉功能障碍 (CROD) 的患者显示出更好的术后嗅觉改善. 这表明皮质类固醇反应是CRS患者保留功能和可逆性的预测指标.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 鼻科 鼻科是指鼻科的专家.
- 嗅觉功能障碍研究研究
背景情况:
- 慢性鼻炎 (CRS) 通常涉及嗅觉功能障碍.
- 皮质类固醇治疗可以改善CRS中的嗅觉,这表明可逆性.
- 手术前的嗅觉评估对于预测手术结果至关重要.
研究的目的:
- 为了确定是否自我报告的手术前的皮质类固醇反应性嗅觉功能障碍 (CROD) 预测CRS患者经过鼻手术后的术后嗅觉改善.
- 评估CROD作为手术后嗅觉恢复的预后因素.
主要方法:
- 对253名患有手术前嗅觉功能障碍的耐火性CRS患者进行前性观察性研究.
- 根据调查,患者被分类为对皮质类固醇有反应或没有反应.
- 使用鼻子棒,OCES,QOD-NS和SNOT-22进行术前和术后评估的嗅觉结果.
主要成果:
- 患有CROD的患者更有可能患上诸如鼻多重症,喘和阿司匹林敏感性等并发症.
- CROD组在嗅觉裂内镜评分 (OCES) 和嗅觉障碍问卷 (QOD-NS) 评分中显示出明显更好的术后改善.
- 这些发现突出了皮质类固醇反应能力和增强的嗅觉恢复之间的相关性.
结论:
- 皮质类固醇反应是CRS患者保持嗅觉功能和可逆性的有价值的临床预测指标.
- 自我报告的CROD可以作为预测术后嗅觉改善的简单预后因素.
- 这项研究支持使用皮质类固醇反应评估来管理CRS中的嗅觉功能障碍.
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