免费的水可以预测孤立的REM睡眠行为障碍中的勒维体痴呆症
Celine Haddad1,2, Véronique Daneault1, Violette Ayral1,3
1Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, CIUSSS-NÎM, Montreal, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|September 19, 2025
概括
梅纳特基底核 (NBM) 中的自由水 (FW) 可以预测孤立的快速眼动睡眠行为障碍 (iRBD) 患者的勒维体 (DLB) 发展的痴呆症. 这种大脑生物标志物与认知衰退和DLB进展有关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 孤立的快速眼动睡眠行为障碍 (iRBD) 经常先于像痴呆症 (DLB) 和帕金森病 (PD) 这样的同核蛋白病.
- 目前iRBD中缺乏针对特定的转换轨迹的预测生物标志物.
- 了解这些轨迹对于早期诊断和干预至关重要.
研究的目的:
- 调查免费水 (FW) 扩散磁共振成像 (dMRI) 措施在iRBD中预测现象转换的实用性.
- 使用脑成像生物标志物区分转化为DLB和PD.
- 评估FRW与iRBD患者认知衰退的相关性.
主要方法:
- 一项多中心的dMRI研究,涉及261名iRBD患者和177名对照.
- 在Meynert的基底核 (NBM) 和后部黑色物质 (SN) 中测量FW.
- 对230名iRBD患者进行了时间到事件分析,并提供了随访数据,以评估向DLB或PD转变的现象.
主要成果:
- 与非转换者相比,转换为DLB或PD的患者在NBM和后部SN中显示出更高的FW.
- 在NBM中的FW是转换到DLB而不是PD的重要预测因素.
- 虽然NBM的交易量也预测了DLB的转换,但当两者一起考虑时,FW仍然是显著的预测因素. 在NBM中的FW与较低的蒙特利尔认知评估 (MoCA) 成绩相关.
结论:
- 在NBM中的FW作为认知衰退和DLB进展在iRBD中的敏感生物标志物.
- 这种生物标志物在预测DLB转换方面优于NBM体积,并支持其在早期患者分层中使用.
- 在NBM中的FW特别确定了转换为DLB,突出了其在差异化转换中的作用.
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