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iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Updated: Jan 17, 2026

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

Published on: March 8, 2015

通过抑制IL-6/IL-6R信号来准RPE衰老,用于治疗视网膜退行性疾病.

Tian Zhou^1,2, Ziqi Yang^1,2, Biyan Ni^1,2

¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Investigative ophthalmology & visual science

|September 19, 2025

概括

干白素-6 (IL-6) 信号传递驱动视网膜色素表皮 (RPE) 细胞衰老和退化. 用tocilizumab抑制IL-6或其受体 (IL-6R) 挽救衰老的RPE细胞,并防止视网膜退化.

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Isolation, Culture, and Genetic Engineering of Mammalian Primary Pigment Epithelial Cells for Non-Viral Gene Therapy

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Last Updated: Jan 17, 2026

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

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科学领域:

眼科医生眼科眼科
细胞生物学细胞生物学
免疫学免疫学免疫学

背景情况:

渐进性视网膜色素表皮 (RPE) 细胞功能障碍是视网膜退化和失明的关键驱动因素.
细胞衰老和RPE细胞中的炎症是视网膜退化的标志,但根本机制尚未完全理解.

研究的目的:

调查IL-6/IL-6R轴是否诱导RPE细胞衰老.
评估抑制RPE衰老和视网膜退化的治疗潜力.

主要方法:

已确定的酸诱导的视网膜退化小鼠模型.
使用IL-6中和抗体或托西利祖马布 (IL-6R抑制剂).
使用分子和成像技术评估RPE衰老,视网膜结构和功能.

主要成果:

在依赖IL-6/IL-6R轴的NaIO3诱导退化中观察到RPE衰老.
IL-6加剧了RPE衰老和视网膜退化;IL-6抑制促进了恢复.
对于IL-6诱导的RPE衰老来说,STAT3激活至关重要;托西利祖马布阻断了这一途径.

结论:

IL-6/IL-6R/STAT3通路对于RPE衰老至关重要.
托西利祖马布通过减轻RPE衰老来治疗视网膜退行性疾病的治疗潜力.