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Updated: Jan 17, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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通过乙化激活T细胞内在的p53,引起抗瘤免疫力,以促进癌症免疫疗法

Xiaojun Yan1, Wenbin Xu1, Han Yao1

  • 1State Key Laboratory of Common Mechanism Research for Major Diseases & Department of Medical Genetics, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Cancer discovery
|September 19, 2025
PubMed
概括

在T细胞内在的p53乙化激活IFN-γ通路,在免疫治疗期间增强CD8+T细胞透和抗瘤免疫力. 这种模仿乙化的p53增强了免疫反应,揭示了p53在癌症治疗中的非瘤细胞自主作用.

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