在皮肤T细胞淋巴瘤患者的细菌皮肤殖民和全身抗生素治疗
Huizhong Wang1,2,3, Shanshan Li4,5, Yujie Wen1,2,3
1Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.
概括
细菌性皮肤殖民,包括黄金葡萄球菌 (SA),在皮肤T细胞淋巴瘤 (CTCL) 患者中很常见. 然而,无论是殖民化还是短期使用抗生素都不会影响CTCL患者的生存率.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 皮肤T细胞淋巴瘤 (CTCL) 患者经常经历细菌性皮肤殖民,特别是金黄色葡萄球菌 (SA).
- 了解殖民化的风险因素及其预后影响对于患者管理至关重要.
研究的目的:
- 在CTCL患者中确定与细菌和SA皮肤殖民相关的风险因素.
- 评估殖民化和全身抗生素使用对CTCL预后的影响.
主要方法:
- 对113名CTCL患者进行皮肤抽样检测的回顾性分析.
- 多变量和单变量分析以确定风险因素.
- 考克斯回归分析用于评估生存结果.
主要成果:
- 观察到细菌 (75.2%) 和SA (60.2%) 皮肤殖民的高患病率.
- 性病变是殖民化的重要风险因素.
- 晚期,瘤,红皮病,淋巴缺血症和乙素友爱症与增加的殖民风险有关.
结论:
- 性病变是亚洲CTCL患者细菌/SA殖民的主要危险因素.
- 无论是细菌/SA皮肤殖民还是短期抗生素治疗都与这一队列的整体存活率较差无关.
- 研究结果表明,殖民并没有显著改变CTCL的预后.
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