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Updated: Aug 1, 2026

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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单细胞可塑性和HLA-DR表达在X结合的AGAMMAGLOBULINEMIA患者

Hasibe Artac1, Ayca Ceylan2, Ilknur Kulhas Celik2

  • 1Division of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Selcuk University, Konya, Turkey. artachasibe@gmail.com.

Immunologic research
|September 19, 2025
PubMed
概括

患有X链接的亚甲基球蛋白血症 (XLA) 的患者表现出改变的单细胞子集和增加的HLA-DR表达,这可能表明补偿性先天免疫反应. 这些变化,以及单细胞可塑性,可能会预测诸如支气管炎症等并发症.

关键词:
布鲁顿的铁氨基激酶.一个单细胞的HLA-DR.单细胞可塑性 单细胞可塑性与X相关的阿玛球蛋白血症.

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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
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Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...