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Updated: Jul 11, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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在 Lysophosphatidic 酸 (LPA) 诱导后出血性水脑炎的优化模型中的神经炎症

Paloma Sánchez-Pavón1, Carter R Palmer1, Christine S Liu1

  • 1Center for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

Neurochemical research
|September 19, 2025
PubMed
概括

研究人员确定了在早产婴儿中驱动后出血头症 (PHH) 的微质通路. 针对这些途径,以及LPA受体,可能为这种神经疾病提供新的治疗策略.

关键词:
Lysophosphatidic 酸 是 一 种 溶解 酸 的 .微质细胞中的微质细胞神经炎症是一种神经炎症.经出血后的水脑.一个单细胞RNA-seqq.

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Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...