偏头痛患者中阿片类药物的使用:OVERCOME (美国) 研究的结果
Sait Ashina1, Elizabeth Johnston2,3, E Jolanda Muenzel4
1Department of Neurology and Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Pain and therapy
|September 19, 2025
概括
治疗偏头痛的阿片类药物使用在美国很常见,与使用推的急性药物,巴比图रेट和紧急护理有关. 减少这些因素是限制偏头痛患者使用阿片类药物的关键.
科学领域:
- 神经学 神经学
- 疼痛管理 疼痛管理
- 公共卫生 公共卫生
背景情况:
- 尽管美国的专家建议不使用阿片类药物治疗偏头痛,但阿片类药物的使用仍然存在.
- OVERCOME (偏头痛流行病学,治疗和护理观察调查) 研究提供了关于偏头痛治疗模式的数据.
研究的目的:
- 评估目前在美国成年人中使用阿片类药物的患病率和相关因素.
- 在偏头痛管理中识别与阿片类药物使用相关的特征.
主要方法:
- 这是一项基于人口统计学代表性的美国成年人样本 (2018-2020) 的观察性,纵向,基于网络的调查.
- 纳入标准:偏头痛 (ICHD-3) 的诊断和过去12个月内至少一次头痛.
- 分析包括人口统计和临床特征的横截面评估,以及多变量建模 (机器学习和后勤回归) 以确定与阿片类药物使用相关的因素.
主要成果:
- 在61,932名患有主动偏头痛的受访者中,21.5%报告目前使用阿片类药物.
- 阿片类药物使用者更有可能使用烟草/大麻,有并发症,经历更高的偏头痛相关残疾,并具有更高的间接负担.
- 与当前阿片类药物使用强烈相关的因素包括服用推的急性偏头痛药物 (OR,10.1),巴比图拉特 (OR,2.2),以及寻求偏头痛紧急/紧急护理 (OR,1.7).
结论:
- 在偏头痛中使用阿片类药物与使用推的急性治疗,巴比图रेट和急诊室访问有关.
- 了解和解决这些相关因素对于制定减少在偏头痛管理中依赖阿片类药物的战略至关重要.
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