艾滋病毒感染者的认知虚弱的患病率和危险因素
Jovana Milic1, Stefano Calza2, Luca Lazzarini3
1Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena.
AIDS (London, England)
|September 19, 2025
概括
认知虚弱 (CF) 影响6.8%的50岁以上的艾滋病毒感染者,比一般老年人群的患病率更高. 下极点CD4计数和多种药物是该群体中CF的关键风险因素.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 认知虚弱 (CF) 是虚弱和认知障碍的同时发生.
- 结核病是不良健康结果的重要预测因素.
- 了解艾滋病毒感染者的CF对于有针对性的干预至关重要.
研究的目的:
- 为了确定50岁以上的艾滋病毒感染者 (PWH) 认知虚弱的患病率.
- 在这个特定的人群中确定与认知脆弱相关的风险因素.
主要方法:
- 摩德纳艾滋病毒代谢诊所 (MHMC) 的横截面观察研究.
- 使用Cogstate电池评估的神经认知功能;认知障碍以全球缺陷评分>0.5.5来定义.
- 使用37项脆弱指数评估脆弱性;分数>0.26表示脆弱性.
主要成果:
- 包括1258名PWH (73%是男性,平均年龄为58岁).
- 认知虚弱 (CF) 的患病率为6.8%.
- 增加的年龄,较低的CD4+细胞计数和多药性与CF有显著的关联.
结论:
- 在50岁以上的PWH患者中,CF的患病率高于一般老年人群.
- 纳迪尔CD4+细胞计数和多种药物被确定为CF的HIV特异性风险因素.
- 这些发现强调了监测和管理老化PWH中CF的必要性.
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