在后COVID状态下与认知表现相关的因素:多变量分析.
Cristina Delgado-Alonso1, María Díez-Cirarda1, Carlos Pérez-Izquierdo2
1Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria "San Carlos" (IdISSC), Madrid, Spain.
概括
后COVID状态 (PCC) 的认知功能障碍受到住院,年龄,性别以及疲劳和抑郁症等并发症的影响. 这些因素相互作用,根据疾病的严重程度和感染波的影响,影响注意力,记忆和执行功能不同.
科学领域:
- 神经科学是一个神经科学.
- 临床医学 临床医学
- 心理学 心理学 心理学
背景情况:
- 认知功能障碍或"脑雾"是COVID后疾病 (PCC) 的常见和持久症状.
- 导致PCC认知障碍的具体因素尚未完全理解,需要对临床,人口和并发症影响进行进一步调查.
研究的目的:
- 研究临床变量 (疾病严重程度,发病以来的时间,感染波,再感染),人口因素 (年龄,教育,性别) 和并发症 (疲劳,抑郁) 对PCC患者的认知表现的影响.
主要方法:
- 对236名PCC患者和148名对照患者进行了全面的临床和神经心理评估.
- 从标准化和计算机化电池进行的18项测试评估了认知功能,包括注意力,记忆力和执行功能.
- 线性模型被用来分析各种因素对认知结果的影响和相互作用.
主要成果:
- 在急性COVID-19期间住院显著影响了注意力,记忆力和执行功能. 老年住院患者表现出比年轻患者更好的认知表现.
- 疲劳和抑郁是显著的共同变量,它们对认知的影响根据住院状态和感染浪潮而有所不同.
- 虽然性别影响了注意力测试,但再感染和发病后的时间与认知表现没有显著的关联.
结论:
- 在PCC的认知表现是多因素的,临床,人口和并发症因素之间的复杂相互作用.
- 住院,疲劳,抑郁,年龄,性别和感染波是PCC认知结果的关键决定因素.
- 了解这些促成因素对于未来研究PCC认知功能障碍的病理生理学和治疗至关重要.
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