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爱斯坦-巴尔病毒和自发性淋巴状细胞系:建立,分子特征,免疫调节和治疗洞察力

Adekunle A Adeniran1, Gavin Giovannoni1, David Baker1

  • 1Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, United Kingdom.

Clinical and experimental immunology
|September 19, 2025
PubMed
概括

自发性淋巴细胞细胞系 (S-LCLs) 在没有直接感染爱斯坦-巴尔病毒 (EBV) 的情况下出现,为研究EBV驱动的疾病提供了有价值的模型. 各种方法和临床背景突出了它们在推进治疗策略中的有用性.

关键词:
乙细胞是B细胞的一个组成部分.爱斯坦·巴尔病毒 (EBV)嵌合式抗原受体T细胞 (CAR-T)多发性硬化症 (MS) 是一种疾病.自发性淋巴细胞细胞系 (S-LCL)

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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