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在OASIS联盟:整合多omics技术,以改变化学品安全评估

David Rouquié¹, Andreas Bender^2,3,4, Jaime Cheah⁵

¹Toxicology Data Science, Bayer SAS Crop Science Division, Sophia Antipolis, 06906, France.

Toxicological sciences : an official journal of the Society of Toxicology

|September 19, 2025

概括

下一代风险评估 (NGRA) 使用先进的高级风险评估.

科学领域:

毒理学和药理学毒理学和药理学
生物技术是生物技术.
计算生物学计算生物学

背景情况:

传统的化学安全动物试验在预测人类反应方面存在局限性.
下一代风险评估 (NGRA) 旨在加强化学品安全评估.
新方法方法 (NAM) 对于减少动物使用和提高预测准确性至关重要.

研究的目的:

开发和验证化学品安全评估的综合方法.
改进体外数据转化为体外人类相关性.
为各种行业建立强大的监管科学方法.

主要方法:

综合安全签名评估的OMICS联盟 (OASIS) 集成了多omics数据 (转录组学,蛋白质组学,细胞绘画).
使用多样化的细胞模型系统,从简单的培养到器官类型模型.
将omics数据与内部曝光估计相结合,用于全面分析.

主要成果:

该OASIS战略旨在提高安全评估的预测能力.
专注于改善生物效应在化学和生物空间的转化,使用肝脏作为一个用例.
利用现有的毒理学数据对特征很好的化合物来改进方法.

结论:

OASIS方法为更具预测性,高效性和成本效益的毒理学模型提供了一条途径.
旨在减少在化学安全评估中对动物试验的依赖.
通过提供经过验证的综合安全评估方法,为监管科学的进步做出贡献.

关键词:

细胞油漆细胞油漆下一代风险评估 (NGRA) 是一种风险评估.肝毒性肝毒性肝毒性新方法方法论 (NAMs)俄米克斯 (omicsics) 是一个电子产品.

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