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Updated: Jan 17, 2026

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遗传性细胞状态塑造了癌细胞中药物持续性相关性和种群动态

Anton Iyer1, Adrian Alva1, Adrián E Granada2

  • 1Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Bangalore, India.

PLoS computational biology
|September 19, 2025
PubMed
概括

耐药性持久体 (DTPs) 从先前存在的细胞状态中出现,而不仅仅是药物后的动态. 这些遗传状态决定了癌症治疗的耐药性,独立于细胞分裂或死亡率.

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