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肺癌微环境的转录状态揭示了与疾病进展相关的巨细胞亚型动态

Duygu Keremitçi¹, Özlem Tuna¹, Aissa Houdjedj^2,3

¹Faculty of Engineering, Bioengineering Department, Ege University, Izmir, Türkiye.

Journal of immunology (Baltimore, Md. : 1950)

|September 19, 2025

概括

研究人员在肺癌中分类了7种瘤相关巨细胞 (TAM) 亚型. 脂质相关的TAMs促进瘤生长和预后不佳,提供潜在的治疗点.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

瘤微环境 (TME) 极大地影响肺癌免疫力和治疗疗效.
瘤相关巨细胞 (TAMs) 具有多种功能,但它们的亚型和作用尚未完全理解.

研究的目的:

为了完善肺癌中TAM亚型的分类.
调查不同TAM群体的功能专业化和临床相关性.

主要方法:

单细胞RNA测序,空间转录组学和来自肺癌队列的临床数据的综合分析.
层次分类和基于细胞的基因评分来定义TAM亚型.
空间和生存分析以评估TAM比率的临床影响.

主要成果:

定义了7种独特的TAM亚型,具有独特的转录特征.
鉴定了与脂质相关的TAM,随着疾病的进展而增加,并表现出免疫抑制特征.
发现较高的脂质关联与组织驻留TAM的比率与晚期肺癌和更差的存活率相关.

结论:

大细胞在肺癌TME中表现出显著的异质性.
与脂质相关的TAMs代表了肺癌中潜在的预后生物标志物和治疗标.
精制的TAM签名提高了癌症研究中的空间转录组分析的分辨率.

关键词:

肺癌是一种肺癌.转录组子状态转录组子状态与瘤相关的巨细胞.

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