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Updated: Jan 17, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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DOT1L介导的H3K79me2指导B细胞谱系的建立,边缘区域的发展和生殖中心的功能

Liam C Kealy1,2, Brendan E Russ2,3, Stephen J Turner2,3

  • 1Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

Journal of immunology (Baltimore, Md. : 1950)
|September 19, 2025
PubMed
概括

端粒沉默1-样 (DOT1L) 干扰剂对B细胞发育至关重要,调节基因表达和细胞周期. 它的缺失会影响B细胞成熟,边缘区域形成和生殖中心反应.

关键词:
B细胞的发育过程DOT1LL 在线播放H3K79me2是什么意思发芽中心的发芽中心.边缘区域边缘区域的边缘区域

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