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对来自塞内加尔的碳烯酶产生性肠杆菌的分子洞察

Ousmane Sow¹, Saoussen Oueslati², Issa Ndiaye¹

¹Pole of Microbiology, Pasteur Institute of Dakar, Dakar, Senegal.

The Journal of antimicrobial chemotherapy

|September 19, 2025

概括

在塞内加尔,产生卡巴酶的肠道细菌 (CPE) 构成越来越大的威胁,鉴定了NDM-5和OXA-181基因. 这项研究强调了对预防CPE传播的监测和干预的迫切需要.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
基因组学就是基因组学.

背景情况:

生产碳酶的肠杆菌 (CPE) 构成全球健康风险,特别是在资源有限的环境中.
这项研究调查了塞内加尔达喀尔的CPE感染的流行率和分子特征.

研究的目的:

在达喀尔帕斯图尔研究所确定CPE在感染中的流行率.
描述单独的CPE菌株的分子特征,包括耐药性基因和遗传关系.

主要方法:

从2019年1月到2020年12月,收集了对埃尔塔尼姆敏感性降低的肠细菌分离物.
碳酶检测涉及生物化学和免疫染色学测定.
全基因组测序 (WGS) 用于分析抗体,MLST,等离子体,毒性基因和遗传相关性.

主要成果:

在1045个Enterobacterales分离物中,有19个 (2%) 被证实为CPE,包括大肠杆菌,Enterobacter spp.和Klebsiella spp.
最常见的碳烯酶基因是blaOXA-48 (35%),blaOXA-181 (35%) 和blaNDM-5 (30%).
像大肠杆菌ST410这样的高风险克隆与来自塞内加尔返回的患者的分离物有着密切的遗传联系,这表明跨国传播. 一些CPE隔离物表现出对较新的抗生素敏感性降低.

结论:

这项研究确定了塞内加尔NDM-5和OXA-181碳酶基因的传播.
它报告了NDM-5和OXA-48在撒哈拉以南非洲首次同时出现的情况.
这些发现强调了加强监测和有针对性的干预措施的必要性,以打击CPE的传播,特别是高风险的克隆.

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