脂蛋白E e4状态预测了老年拉丁裔/拉丁裔成年人的记忆性能和日常功能.
Jennifer Lozano1, Ezekiel Hernandez1, Dora Beacham2
1Psychology Department, California State University San Marcos, San Marcos, CA, USA.
概括
在老年拉丁裔中,阿波利波蛋白 (APOE) e4状态预测阿尔茨海默病和相关痴呆症 (ADRD) 的认知和功能衰退比单独的家族史更好. 这凸显了在这个日益增长的人口群体中需要有针对性的干预措施的需要.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 遗传学 遗传学 是一个
背景情况:
- 西班牙裔/拉丁裔人口面临到2060年,阿尔茨海默氏症和相关痴呆症 (ADRD) 预计增加不成比例.
- 阿波利波蛋白 (APOE) e4基因和家族史是已知的痴呆症风险因素,但它们对西班牙裔/拉丁裔成年人的认知和功能结果的具体影响尚不清楚.
研究的目的:
- 调查APOE e4状态和家族认知障碍病史对老年西班牙裔/拉丁裔成年人的神经心理表现和日常功能的预测作用.
- 检查这些风险因素在这个人口群体中的潜在主要和相互作用影响.
主要方法:
- 分析了国家阿尔茨海默氏症协调中心队列中475名老龄化的西班牙裔/拉丁裔成年人的数据.
- 评估神经心理表现和信息人报告的日常功能.
- 统计检查APOE e4状态和家族史的主要和相互作用效应.
主要成果:
- 与e4-阴性参与者相比,APOE e4-阳性参与者表现出明显较差的口头和视觉回忆.
- APOE e4 状态与告密者报告的日常运作状况较差有关.
- 在听觉注意力方面发现了APOE e4状态和家族史之间的显著相互作用,具有家族史的e4阳性个体表现最好.
结论:
- 在西班牙裔/拉丁裔人口中,APOE e4状态似乎是与ADRD相关的认知和功能结果的更可靠的预测指标,而不是单独的家族史.
- 这些发现强调了在对老年拉丁裔的ADRD风险评估和干预策略中考虑APOE e4状态的重要性.
- 由于预计ADRD患病率增加,因此需要紧急开发干预措施,以维持这一群体的认知和日常功能.
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