药物作为潜在饮食障碍的诱发因素:使用FDA不良事件报告进行不成比例分析
1Department of Psychiatry, Jiangxi Mental Hospital & Affiliated Mental Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330029, Jiangxi, China; Nanchang City Key Laboratory of Biological Psychiatry, Jiangxi Provincial Clinical Research Center on Mental Disorders, Jiangxi Mental Hospital, Nanchang 330029, Jiangxi, China.
Eating behaviors
|September 19, 2025
概括
某些药物可能会引发饮食障碍,特别是在老年人中. 这项研究使用FAERS数据库确定了9种药物,包括奎平和普雷加巴林,作为潜在的诱发因素.
科学领域:
- 药物监督 药物监督 药物监督
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
背景情况:
- 与心理社会因素相比,药物是饮食障碍的未被认可的触发因素.
- 美国食品和药物管理局的不良事件报告系统 (FAERS) 数据库为识别潜在的药物诱导不良事件提供了宝贵的资源.
研究的目的:
- 识别可能与饮食障碍发展相关的药物.
- 分析FAERS数据库的信号,将特定药物与饮食障碍联系起来.
主要方法:
- 从2004年1月到2024年12月,FAERS报告了潜在的饮食障碍.
- 计算了报告赔率比率 (ROR) 并应用了费舍尔的精确测试与邦费罗尼校正.
- 利用LASSO和后勤回归来识别100多份报告和显著的积极信号的沉药物.
主要成果:
- 分析了20145份FAERS报告,62.7%涉及女性,平均年龄为59岁.
- 确定了30种具有显著积极信号的药物.
- 九种药物被确定为潜在的诱发因素:奥克特里奥蒂德,里博西基利布,苏尼蒂尼布,里瓦斯蒂格明,埃弗罗利莫斯,奎蒂亚平,帕尔博西基利布,埃索梅普拉和普雷加巴林.
结论:
- 某些药物可能会导致饮食障碍,特别是在中年和老年人群中.
- 临床医生应监测影响食欲,体重或具有滥用潜力的药物,这些药物在风险人群中具有潜在的滥用潜力.
- 意识到这些药物诱导的风险对于预防饮食障碍患者的伤害至关重要.
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