在发生性自身免疫病事件后,增加了精神病药物的使用
Quinn Goddard1, Gilaad G Kaplan2, Stephanie Coward2
1Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive Northwest - TRW 5E04, Hospital Dr NW, Calgary, AB T2N 4Z6, Canada.
Journal of psychosomatic research
|September 19, 2025
概括
新阳性乳自身免疫 (tTG) 个体显示抗抑郁药和抗精神病药的使用增加. 这凸显了对乳患者精神病状况的监测的需要.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 结核病与患精神疾病的风险更高有关.
- 对于腹腔疾病患者的精神疾病的正式治疗模式尚不清楚.
研究的目的:
- 调查新诊断患有乳性自身免疫症的个体使用精神病药物的情况.
- 为了比较药物使用之前和之后的正面组织转谷氨酶 (tTG) 试验.
主要方法:
- 在加拿大阿尔伯塔省 (2015-2023) 使用行政医疗保健数据进行基于人口的队列研究.
- 连接了对tTG新呈阳性个体的药物处方 (抗抑郁药,抗焦虑药,抗精神病药).
- 药物使用日数 (PDC) 和几率比率 (OR) 的计算比例,包括先前有焦虑/抑郁症诊断的患者的分分析.
主要成果:
- 新增tTG阳性个体显示,抗抑郁药 (27.6%对22.5%) 和抗精神病药 (6.0%对4.6%) 的发行增加,几率更高 (OR=1.22).
- 在tTG后,抗抑郁药 (21.1%对2.8%) 和抗精神病药 (6.3%对0.4%) 的PDC中位数显著增加.
- 之前被诊断患有焦虑/抑郁症的个体的药物开放率下降 (OR=0.42) 和tTG后较低的中位数PDC.
结论:
- 研究结果表明,需要加强对乳患者群体中精神伴随性疾病的查和监测.
- 进一步的研究是有必要的,以了解增加的精神病药物使用后的原因后tTG阳性.
- 这项研究强调了乳病和心理健康治疗模式之间的复杂关系.
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