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Updated: Jan 17, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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哺乳动物异染色的建立和表观遗传稳定性的要求

Antonis Tatarakis1, Harleen Saini1, Juntao Yu1

  • 1Howard Hughes Medical Institute, Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

Molecular cell
|September 19, 2025
PubMed
概括

建立和维护DNA异染色质需要特定的分子参与者. 这项研究表明,虽然短暂的异性染色素是短暂的遗传,但稳定的域依赖于通过DNA甲基化和其他途径的分化和强化.

关键词:
这是一个CRISPR屏幕.通过DNA甲基化.H3K9me3是什么意思 H3K9me3是什么意思聚合的多元.表观遗传遗传是一种表观遗传遗传.异性染色是一种异性染色.印记是为了印记.mESCs是什么意思

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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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