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用于骨组织工程的氧化二酸盐水泥的配方,体外物理化学和生物评估

L Touati¹, C Leroy², C Damia³

¹CIRIMAT, Toulouse INP, Université de Toulouse, CNRS, 4 allée Emile Monso, Toulouse cedex 4, 31030, France.

Acta biomaterialia

|September 19, 2025

概括

一种新型的氧化二酸盐 (CPPD) 水泥显示,与酸盐水泥相比,炎症减少. 这种配方提供了一种稳定,生物活性的骨替代品,具有可调节的特性,可增强骨再生.

科学领域:

生物材料科学生物材料科学
生物矿物化生物矿物化
整形外科的研究研究.

背景情况:

酸铁二 (CPPD) 晶体与骨关节炎炎症有关.
基于CPPD的材料显示出作为生物活性骨替代品的潜力.
现有的仿生水泥可能会引起炎症反应.

研究的目的:

评估制定单临床CPPD (m-CPPD) 水泥 (m-CPPDc) 的可行性.
为了比较m-CPPDc的炎症潜力与生物模拟碳酸酸盐水泥 (Apc).
探索双相水泥组合物对调制的吸收能力和炎症反应的研究.

主要方法:

开发了一种原创的方法,结合了 орто和酸离子定位.
使用人类介质干细胞 (hMSC) 和酶试验 (ALP) 进行了体外生物试验.
在各种水性介质 (SBF,TRIS缓冲) 中进行了无细胞水泥物理化学演变测试.

主要成果:

m-CPPDc诱导的互白素-1β产量比Apc低2倍,比单独的m-CPPD晶体低2.5倍.
通过调整配方参数,实现了双相水泥组合 (m-CPPD与m-CPPT-β).
通过ALP和hMSC的作用,证明了释放的酸盐离子的增强水解,释放的和正酸盐离子比Apc.

结论:

开发的水泥配方策略使得可以制造纯或双相CPPD水泥.
m-CPPDc具有较低的炎症潜力,细胞相容性和在水性介质中的高稳定性.
这种新的酸盐水泥家族在体外具有内在的生物反应,为先进的骨再生材料铺平了道路.

关键词:

骨头水泥骨头水泥是什么意思酸铁二二酸盐二水合物细胞相容性细胞相容性具有潜在的炎症性.物理化学表征的物理化学表征.

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