不同类型的纳米塑料在与精液相关的度下对人类精子产生不同程度的毒性
Yujie Wang1, Yanfan Cui1, Yixuan Li1
1School of Basic Medical Sciences, Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, China.
Reproductive toxicology (Elmsford, N.Y.)
|September 19, 2025
概括
像聚乙烯 (PE) 这样的纳米塑料 (NP) 损害精子功能,降低生命力和运动性. 聚烯 (PP) NP 没有显示有毒性,而混合物加剧了损伤,突出了对男性生殖的各种NP风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 人类精液中越来越多地检测到纳米塑料 (NP).
- 以前的毒性研究主要集中在聚乙烯 (PS) NPs.
- 了解各种NP类型对男性生殖健康的影响至关重要.
研究的目的:
- 为了量化人类精液中的多个NP类型.
- 评估聚烯 (PP),聚乙烯 (PE) 和聚乙烯二甲 (PET) NP对人类精子功能的毒性,在相关度下.
- 研究NP混合物对精子参数的影响.
主要方法:
- 热解气色谱-质谱学 (Py-GCMS) 用于识别和量化人类精液中的NP.
- 人类精子在与精液相关的度中暴露于PP,PE和PETNP.
- 评估了精子的活力,运动性,透能力,线粒体膜潜力 (MMP),活性氧物种 (ROS) 和氧化应激.
主要成果:
- PE显著降低了精子的活力,运动性,透性和MMP,诱导了氧化应激.
- 对PET的暴露降低了精子的运动性,透率和MMP,但没有影响生命力或ROS.
- PP对精子功能没有不利影响;与单个NP类型相比,NP混合物随着时间的推移会引起更明显的损害.
结论:
- 不同的NP类型对人类精子具有不同的毒性,PE是最有毒的,PP在观察到的度下没有毒性.
- NP混合物反映了现实世界的暴露,并且可以比单个NP引起更大的生殖障碍.
- 这些发现凸显了环境纳米塑料对男性生殖健康的潜在风险.
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