运动认知衰老:运动皮层及其路径的作用
Jiaqi Wen1, Zifei Liang2, Chenyang Li2
1Department of Radiology, NYU Grossman School of Medicine, NY, NY 10016, USA; Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
老龄化导致大脑变化,影响运动和认知功能. 皮质干管 (CStrT) 起着关键作用,调解与运动皮质 (M1) 缩相关的衰退.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 神经成像是一种神经成像.
背景情况:
- 运动和认知能力下降是衰老的特征.
- 在初级运动皮层 (M1) 中的金字塔神经元形成皮质脊髓管 (CST) 和皮质状管 (CStrT).
- 与CST相比,CStrT在衰老中的作用是不太了解的.
研究的目的:
- 为了研究M1结构和血液动力学中与年龄相关的变化.
- 为了评估CST和CStrT的微结构完整性与老化.
- 确定CST和CStrT完整性是否调解M1缩和功能衰退之间的联系.
主要方法:
- 对339名健康成年人 (36-90岁) 的MRI数据 (T1/T2加权,ASL,扩散MRI) 的分析.
- 使用沿途分析评估了M1,CST和CStrT的与年龄相关的轨迹.
- 调解分析检查了M1缩,通道完整性和运动/认知性能之间的关系.
主要成果:
- 衰老的M1显示体积减少,血液动力学和结构改变.
- CST在M1附近表现出局部退化,而CStrT显示出更广泛的退化.
- CST和CStrT完整度调解了M1缩和运动和认知衰退之间的关联.
结论:
- 衰老会导致M1及其通路的结构和功能退化.
- 该CStrT被确定为关键的调解者,将M1缩与运动和认知能力下降联系起来.
- 健康衰老的规范性成像标志物可能有助于早期发现神经退行性疾病.
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