患有Fontan息的患者的透支功能障碍与死亡和心脏移植有关
Edward H Hardison1, Christopher C Henderson2, Rachel K Duncan3
1Division of Pediatric Cardiology, Primary Children's Hospital at the University of Utah, Salt Lake City, Utah, USA.
概括
心血管磁共振 (CMR) 可以检测Fontan患者的透支功能障碍,识别那些有更高风险的不良结果,如死亡或移植. 这有助于更早地诊断和管理Fontan衰竭.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 心血管成像 - 心血管成像
背景情况:
- 成年人患有丰丹衰竭 (FF) 呈现变化,往往是晚诊断.
- 对于FF的预测因素仍然不清楚.
- 扩张功能障碍是Fontan息后不良结果的潜在指标.
研究的目的:
- 调查心血管磁共振 (CMR) 参数,以识别Fontan患者的透静功能障碍.
- 为了确定透缩功能障碍是否与Fontan群体的不良结果有关.
主要方法:
- 将Fontan患者 (N=98) 与健康对照组 (N=96) 进行比较.
- 通过死亡,移植,失去蛋白质的肠道病变,低峰VO2或尿液需求来定义Fontan衰竭 (FF).
- 使用CMR来测量腹功能变量,包括峰值填充率 (PFR) 和PFR与终端腹体积 (EDV) 进行索引.
主要成果:
- 与对照组相比,Fontan患者表现出更糟糕的透析功能 (降低PFR,PFR/EDV;增加TPFR).
- 与没有失败的患者相比,Fontan失败患者 (N=39) 的PFR/EDV降低,心室质量指数较高 (N=59).
- 晚期加多增强在FF队列中更为普遍.
结论:
- 在Fontan人群中,CMR有效地识别了透缩功能障碍.
- 通过CMR检测到的更差的透静功能与Fontan循环患者的死亡或心脏移植有关.
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