人环素对基因组高风险,节点阴性,HR阳性/HER2阴性乳腺癌的影响
N Chen1, J Q Freeman2, S Yarlagadda1
1Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, USA.
概括
对于高风险 (RS ≥31) 早期乳腺癌患者来说,在纳税化疗中添加 antracyclines 改善了结果. 基因组复发评分 (RS) 测试可能比传统因素更好地预测 antracycline 的益处.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 临床试验 临床试验
背景情况:
- 在高复发率评分 (RS) 乳腺癌中,抗环素的益处是不确定的.
- 复发率评分 (RS) 指导HR+/HER2-乳腺癌的辅助化疗.
- 这项研究研究了在高RS患者中环素的作用.
研究的目的:
- 评估是否将人环素添加到税化疗中可以改善RS≥31患者的治疗结果.
- 评估基因组RS的预测价值,以评估它对人环素的益处.
主要方法:
- 在TAILORx试验中对2549名RS≥11.0的患者进行分析.
- 纳与环胺 (TC) 的比较与纳与人环素/环胺 (T-AC) 的比较.
- 评估结果:远程无复发间隔 (DRFI),远程无复发生存率 (DRFS) 和总生存率 (OS),控制共变量. 用于分析RS-依赖益处的线条回归.
主要成果:
- 在RS≥31的患者中,与TC相比,T-AC改善了DRFI (96.1%对91.0%) 和DRFS (95.4%对89.8%).
- 与T-AC.一起观察到改善整体存活 (OS) 的趋势.
- 支线回归表明,在RS较高的情况下,人环素的益处越来越大.
结论:
- 患有高基因组风险 (RS ≥31) 早期HR+/HER2-乳腺癌的患者可能会受益于添加到纳类化学疗法中的 antracyclines.
- 基因组RS可能比临床病理因素更准确地预测人环素的益处.
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