适合的国内带血移植的可用性,适用于血液恶性病的成年整体移植接受者
Anne Archer1, Warren B Fingrut2, Luzmary Alvarez1
1Bone Marrow Transplant and Cell Therapy Program, Weill Cornell Medicine/ NewYork-Presbyterian, New York, New York.
Transplantation and cellular therapy
|September 19, 2025
概括
带血 (CB) 移植可以克服需要移植的不同患者的捐赠者获取差异. 美国库存为大多数患者 (包括少数群体) 提供合适的双双CB (dCB) 单元,改善了移植获取.
科学领域:
- 血液学 血液学 血液学
- 移植免疫学 移植免疫学
- 公共卫生 公共卫生
背景情况:
- 非相关捐赠者 (URD) 的可用性有限,特别是在非欧洲血统患者中,造成了移植接入障碍.
- 替代性捐赠者,如HLA不匹配的URD或单一的相关捐赠者,具有局限性.
- 尽管它有可能解决捐赠者获取不平等问题,但带血 (CB) 移植仍未得到充分利用.
研究的目的:
- 调查双带血 (dCB) 单位在克服供体获取差异方面的潜力.
- 评估美国CB库存对不同患者群体的适用性.
- 评估CB作为紧急移植需求的替代方案.
主要方法:
- 模拟CB搜索对成年整体移植接受者 (第一队列) 进行.
- 分析了最近dCB接受者的移植特征 (第二队列).
- 综合数据评估了2024年美国CB库存对不同患者的容量.
主要成果:
- 在美国库存中的96%的患者中确定了合适的dCB移植.
- 超过90%的欧洲和非欧洲血统患者都有合适的dCB移植.
- 80%的100公斤以上的患者有合适的dCB移植,而87%的患者可以使用家庭设备.
结论:
- 美国CB库存可以显著减轻少数群体的捐助者获取差异.
- dCB移植为紧急移植病例提供了一个可行的替代方案.
- 继续为公共CB银行和移植中心专业知识提供资金至关重要.
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