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在质子束FLASH辐射条件下ESR剂量计的性能评估

Jun Kumagai¹, Hiromitsu Iwata², Kenji Komaguchi³

¹Institute of Materials and Systems for Sustainability, Nagoya University, Furo, Chikusa, Nagoya, Aichi, 464-8603, Japan.

Journal of radiation research

|September 19, 2025

概括

甲酸单 (LFM) 和L-alanine (ALA) 化学剂量计在超高剂量率 (UHDR) 质子辐射下显示剂量依赖的反应. 对于UHDR辐射剂量计,LFM的灵敏度高于ALA.

科学领域:

辐射剂量计是辐射剂量计.
化学物理化学物理
医学物理医学物理

背景情况:

超高剂量辐射率 (UHDR) 辐射,或FLASH,通过节省正常组织,显示出对癌症治疗的希望.
精确的剂量测量对于理解和优化超高频率辐射效应至关重要.
化学剂量计提供了一种测量辐射剂量的方法,但它们在超高强度辐射条件下的性能需要评估.

研究的目的:

为了评估酸盐单化物 (LFM) 和L-氨酸 (ALA) 化学剂量计在UHDR质子辐射下的性能.
使用电子自旋共振 (ESR) 光谱法,比较传统 (CONV) 和UHDR质子辐射下的LFM和ALA的剂量反应.
为了确定这些剂量计在不同辐射条件下的相对有效性 (RE).

主要方法:

电子自旋共振 (ESR) 光谱法用于分析LFM和ALA中的自由基生成.
用CONV和UHDR质子束 (高原和峰值条件) 辐射剂量计.
相对有效性 (RE) 是通过将激素产量与60Co γ-ray辐射进行比较来计算的.

主要成果:

无论是LFM还是ALA,在CONV和UHDR辐射中,ESR信号强度和物理剂量之间都显示出线性相关性.
随着剂量速率和线性能量转移 (LET) 的增加,RE值下降,这表明在UHDR条件下剂量计效率降低.
与ALA相比,LFM表现出大约20%的更高灵敏度,基于ESR中央峰值高度.

结论:

LFM和ALA是UHDR质子辐射的可行的化学剂量计,反应与剂量相关.
观察到的RE的减少表明,在UHDR和更高的LET条件下,基因重组增强.
对于UHDR质子剂量计应用,LFM是比ALA更敏感的剂量计.

关键词:

化学剂量测量ESR化学剂量测量一个闪光灯.氨酸氨酸是什么意思甲酸单化物.质子束是一个质子束.超高剂量速率的超高剂量速率

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